Preceding endoscopic submucosal dissection in submucosal invasive gastric cancer patients does not impact clinical outcomes

Abstract Submucosal deep invasion of gastric cancer (T1b2; depth submucosal ? 500 ?m) is a risk factor for lymph node metastasis and, thus, one the criteria curative treatment. Our aim was to evaluate specific influence endoscopic dissection (ESD) on prognosis patients with T1b2 cancer. This retrospective analysis 248 consecutive patients, 252 pT1b2 lesions, who underwent ESD prior additional surgery (Group A, n = 101) or only B, 147). After propensity score-matching (for sex, age, tumor diameter and gross type), we compared pathological characteristics between 2 groups over follow-up period 60 months. Compared Group in A were older, higher proportion men. The depressed undifferentiated type tumors greater B than larger size as well. There no incidence local recurrence, but distant identified 5% cases 3% B. score-matching, there difference 5-year overall survival rate (87.5% vs. 91.2%, respectively), nor disease-specific (96.3% 96.4%, respectively). did not adversely affect clinical outcomes after surgery.